Dapsone treatment of leprosy

Treatment of leprosy dapsone is almost completely absorbed from the gastrointestinal tract , reaching high concentrations in the blood after drinking 2-8 hours. Concentrations stabilized at about 0.1 to 7 micrograms / ml , the average was 2.3 micrograms / ml after 8 days of treatment at a dose of 200 mg / day . Monoacetyl dapsone and its metabolites via hepatic circulation - intestine .

 Treatment of leprosy dapsone is almost completely absorbed from the gastrointestinal tract , reaching high concentrations in the blood after drinking 2-8 hours. Concentrations stabilized at about 0.1 to 7 micrograms / ml , the average was 2.3 micrograms / ml after 8 days of treatment at a dose of 200 mg / day . Monoacetyl dapsone and its metabolites via hepatic circulation - intestine . The volume of distribution of the drug is 1.5 to 2.5 liters / kg .

 Drug distribution in most tissues of the body such as skin , muscle , kidney and liver . Dapsone in sweat , saliva , sputum , tears and bile . Drugs cross the placenta and excreted in breast milk . The rate of plasma protein binding is 50-90 % , dapsone monoacetyl almost entirely associated with plasma proteins . Excreted primarily in the urine , 20 % as not transformation .
Specifies the treatment of leprosy dapsone
 
Treatment rooms , dermatitis herpetiformis , Pneumocystis carinii.Du malaria .
Contraindications of dapsone treatment of leprosy
 
Allergic to dapsone or sulphonamid ; severe anemia .
 
Exercise caution when using dapsone treatment of leprosy
 
Deficiency of glucose 6 phosphate - dehydrogenase ( G 6PD ) , or methemoglobin reductase . Just be careful with the drugs or the disease agent capable of causing hemolysis and persons related to hemolytic disease ( a bacterial infection , most evidence diabetic ketones ) .
 
Dapsone Precautions for pregnant women
 
Dapsone has been widely used for the treatment or prevention of malaria and treatment rooms , skin problems for a pregnant woman without fetal toxicity or birth defects . So , dapsone may be used for pregnant women .
 
Exercise caution when using dapsone for women breastfeeding period
 
Dapsone treated leprosy drugs excreted into breast milk and because of the considerable amount of carcinogenic potential was seen in experimental animals , should be considered when used for breastfeeding .
 
Undesirable effects ( ADR ) treatment of leprosy dapsone
 
Many hemolysis and methemoglobin levels / blood is dose -related adverse effects The most common and usually occur when doses greater than 200 mg / day . Dose 100 mg / day but rarely causes hemolysis with G6PD deficiency may be affected at a dose of 50 mg / day .

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