Treatment of leprosy dapsone is almost completely absorbed from the gastrointestinal tract , reaching high concentrations in the blood after drinking 2-8 hours. Concentrations stabilized at about 0.1 to 7 micrograms / ml , the average was 2.3 micrograms / ml after 8 days of treatment at a dose of 200 mg / day . Monoacetyl dapsone and its metabolites via hepatic circulation - intestine . The volume of distribution of the drug is 1.5 to 2.5 liters / kg .
Treatment of leprosy dapsone is almost completely absorbed from the gastrointestinal tract , reaching high concentrations in the blood after drinking 2-8 hours. Concentrations stabilized at about 0.1 to 7 micrograms / ml , the average was 2.3 micrograms / ml after 8 days of treatment at a dose of 200 mg / day . Monoacetyl dapsone and its metabolites via hepatic circulation - intestine . The volume of distribution of the drug is 1.5 to 2.5 liters / kg .